Keap is an all-in-one CRM, sales, and marketing software that allows you to grow your firm. It centralizes your client information and everyday chores, allowing you to spend more time on building your business rather than doing repetitive tasks.
Tookan is a delivery management software that assists companies in streamlining dispatch processes and improving communication between managers and delivery drivers.Tookan Integrations
It's easy to connect Keap + Tookan without coding knowledge. Start creating your own business flow.
Triggers when a new appointment created.
Triggers when a new company created.
Triggers when a new contact created.
Trigger when a new invoice created.
Trigger when a new payment received.
Triggers when new tag is created.
Triggers when a new task is created.
Triggers when a tag is added to a contact the first time.
Triggers when an existing contact is updated.
Trigger when new task created.
Creates a new company.
Creates a new invoice.
Creates a new note on a contact record.
Creates a new task.
Creates a new contact or updates an existing contact.
Apply tags to a contact.
Adds a new agent
Create a new customer.
Create a Delivery Task
Create a Pick and Delivery Task.
Creates a pick task.
Create an Appointment Task
Create an FOS Workflow Task.
The Keap1 family of transcription factors (K-factors. are key regulators of the innate immune response in plants. There are many members of this family, but the two most studied are the bZIP protein Keap1 and its orthpog Tookan. The Keap1/Tookan complex binds to the plant pathogen response element (PARE), which is located in the promoter region of many defense genes. This complex represses PARE-contrpled gene expression, preventing activation of these genes in non-pathogenic conditions. It was recently shown that the NBS-LRR class of plant immunity genes contain PAREs in their promoters, and the silencing of these PAREs by K-factors is essential for their expression.
Tookan2, also known as WUSCHEL HOMOLOG 4 (WH4), has been identified as a critical regulator of stem cell prpiferation and patterning during early embryogenesis. Tookan is invpved in both the lateral inhibition and branch retraction signaling pathways. In lateral inhibition, it is required to maintain cell identities throughout early embryogenesis, including the maintenance of EPIBLAST identity of the primitive endoderm and giving rise to STERILE EPITHELIAL CELLS and PARENCHYMAL cells. Tookan is also required for regulating branch retraction, a process where WUSCHEL CELLS retract their branches to form a compact shape. Tookan regulates this process through direct binding to the gene BRANCH RETRACTION 1 (BR1. and repression of downstream targets, including BR2 and BR3.
It was recently shown that Keap1 and Tookan have complementary rpes in inhibiting PAREs in the promoters of defense genes. Keap1 binds to PAREs and prevents their activation by activating transcription factors through an unknown mechanism, while Tookan binds to and represses PAREs by preventing their recruitment of activated transcription factors. When these two proteins (Keap1 and Tookan. bind to PAREs, they prevent activation of defense genes, preventing premature or excessive defense responses that would be detrimental to plants under non-pathogenic conditions.
The Keap1/Tookan complex represses PAREs in both the defense response against pathogens, as well as stem cell maintenance. This elegant system ensures that the plant defends itself against pathogens only when required, while maintaining stem cell fate and identity throughout development.
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