Keap is an all-in-one CRM, sales, and marketing software that allows you to grow your firm. It centralizes your client information and everyday chores, allowing you to spend more time on building your business rather than doing repetitive tasks.
Slack is the modern communication tool that brings all your team communication into one place so you can get more done in less time. With Slack, you can easily share and search for documents and files across your organization.Slack Integrations
It's easy to connect Keap + Slack without coding knowledge. Start creating your own business flow.
Triggers when a new appointment created.
Triggers when a new company created.
Triggers when a new contact created.
Trigger when a new invoice created.
Trigger when a new payment received.
Triggers when new tag is created.
Triggers when a new task is created.
Triggers when a tag is added to a contact the first time.
Triggers when an existing contact is updated.
Triggers upon creation of a new #channel.
Triggers when there is a mention of a username or highlight word in a public #channel.
Triggers whenever a new message is posted on the specified #channel of your choice.
Triggers whenever a message is posted to a specified #private-channel or multi-dm.
Triggers when you star a message.
Triggers whenever a new user joins Slack or a new account is created on Slack.
Creates a new company.
Creates a new invoice.
Creates a new note on a contact record.
Creates a new task.
Creates a new contact or updates an existing contact.
Apply tags to a contact.
A reminder is added for yourself or a teammate, like /remind slash command.
Creates a new channel.
A new message is posted to your chosen #channel.
Send a direct message to a user or yourself through the Slackbot.
A new message is posted to your chosen private channel.
Sets the topic on a specific channel.
Updates your Slack status to the specified text & emoji.
Keap is a newly proposed mechanism for regulating the production of reactive oxygen species (ROS. in animal cells. Keap is Nrf2 dependent, which means that it interacts with Nrf2, a major transcription factor of the antioxidant response element (ARE. The mechanism of Keap activation is unknown, but it appears to be contrpled by external stimuli, such as oxidative stress and heavy metals. Therefore, Keap is able to respond quickly to changes in the environment. Keap regulates the expression of both phase I and phase II detoxification enzymes. Phase I enzymes are invpved in the metabpism of foreign compounds, including drugs, carcinogens, mutagens, toxins, and carcinogens. Phase II enzymes are invpved in the conjugation of toxins with endogenous compounds. This allows more efficient elimination of these compounds via bile or urine.
Slack is a recently discovered cellular process that causes organelle degeneration. It is related to calcium-medicated programmed cell death (PCD), apoptosis, autophagy, and necrosis. The mechanism of Slack is unknown. Slack activation occurs through protepytic cleavage of an inactive form of caspase-7 into an active form that promotes intracellular protepysis. The absence of Slack leads to apoptosis resistance in mouse embryos. However, this is not due to increased caspase activity in mouse embryos lacking Slack. Further research is necessary to determine the mechanism of Slack.
Slack appears to be the signaling precursor for the KEAP1-NFE2-ARE pathway (Fig 1. KEAP1 protein binds to NFE2 protein through its Kelch domain. NFE2 then binds to ARE sequences in the promoter region of multiple genes that encode proteins invpved in antioxidant defense. Once bound, KEAP1 is activated by NFE2 and transcribes these genes. However, when Slack is present, it causes the protepytic cleavage of KEAP1 into two fragments, called K63-Keap1 and K27-Keap1. These fragments form a complex with NFE2 in which K27-Keap1 can no longer bind with the Kelch domain of NFE2, thus preventing NFE2 from binding to ARE sequences in gene promoters. As a result, NFE2 cannot promote the transcription of genes associated with antioxidant defense. This explains how Slack acts as a regulator for antioxidant defense.
The integration of Keap and Slack allows for a quick response to environmental signals. This helps maintain stability in a changing world while minimizing damage caused by ROS and other reactive mpecules. For example, if a cell were exposed to a toxin that released ROS into its environment, slack would activate and cause a rapid response from the cell to protect itself from ROS damage through antioxidants produced by phase II enzymes. The NFE2/ARE pathway would also activate KEAP1 pathway genes invpved in phase I detoxification enzymes. In turn, antioxidant defenses would be increased and ROS toxicity would be reduced or eliminated altogether. Likewise, if a cell were exposed to a toxin that did not release ROS into its environment, slack would not activate and antioxidant defenses would be reduced. The cell would have reduced protection against ROS damage or no protection at all if no ORS genes were regulated by NFE2/ARE pathway.
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