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Keap + Flock Integrations

Syncing Keap with Flock is currently on our roadmap. Leave your email address and we’ll keep you up-to-date with new product releases and inform you when you can start syncing.

About Keap

Keap CRM (formerly Infusionsoft) helps you grow your business, improve customer service & increase sales. Make customers happy.

About Flock

Flock, the best team communication app and online collaboration platform, comes with team messaging, project management and other great features that make your team colloboartion more effective.

Flock Integrations
Connect Keap + Flock in easier way

It's easy to connect Keap + Flock without coding knowledge. Start creating your own business flow.

    Triggers
  • New Appointment

    Triggers when a new appointment created.

  • New Company

    Triggers when a new company created.

  • New Contact

    Triggers when a new contact created.

  • New Invoice

    Trigger when a new invoice created.

  • New Payment

    Trigger when a new payment received.

  • New Tag

    Triggers when new tag is created.

  • New Task

    Triggers when a new task is created.

  • Updated Contact

    Triggers when an existing contact is updated.

    Actions
  • Create Company

    Creates a new company.

  • Create Invoice

    Creates a new invoice.

  • Create Note

    Creates a new note on a contact record.

  • Create Task

    Creates a new task.

  • Create or Update Contact

    Creates a new contact or updates an existing contact.

  • Tag Contact

    Apply tags to a contact.

How Keap & Flock Integrations Work

  1. Step 1: Choose Keap as a trigger app and authenticate it on Appy Pie Connect.

    (30 seconds)

  2. Step 2: Select "Trigger" from the Triggers List.

    (10 seconds)

  3. Step 3: Pick Flock as an action app and authenticate.

    (30 seconds)

  4. Step 4: Select a resulting action from the Action List.

    (10 seconds)

  5. Step 5: Select the data you want to send from Keap to Flock.

    (2 minutes)

  6. Your Connect is ready! It's time to start enjoying the benefits of workflow automation.

Integration of Keap and Flock

Keap?

Keap is a protein complex that regulates the Nrf2-mediated antioxidative and cytoprotective response. It can also inhibit the activity of TGFβ, which is a tumor promoter (Figure 1.

Flock?

Flock is a small protein that impacts Keap by targeting it for degradation. Flock has been shown to degrade Keap in response to oxidative stress and increase the activity of TGFβ (Figure 2.

Integration of Keap and Flock

The Nrf2-Keap pathway is responsible for the majority of the body’s antioxidative and cytoprotective response (Figure 3. Keap and Nrf2 are both induced upon exposure to oxidative stress. Nrf2 then translocates into the nucleus and binds to the antioxidant response element (ARE. in the promoter region of genes responsible for the production of enzymes invpved in the body’s antioxidative and cytoprotective response (Figure 4. These genes are then activated, resulting in the production of antioxidants such as glutathione peroxidase, glutamate–cysteine ligase catalytic subunit, superoxide dismutases, thioredoxin reductases, etc. The production of these antioxidants decreases ROS levels, thereby inhibiting cellular damage caused by oxidative stress. Activation of the Nrf2-Keap pathway is critical for preventing cellular damage.

One way in which Keap can be degraded is through Flock degradation. Flock targets the C-terminal region of Keap, which is no longer protected after translocation to the nucleus. As a result, Keap is rapidly degraded via proteasome-dependent pathways. Consequently, Nrf2 is no longer present in the nucleus, which results in decreased activation of ARE-containing genes. Without activation of ARE-containing genes, there are no antioxidants produced, which results in increased cellular damage caused by oxidative stress (Figure 5. Hence, this degradation pathway can have adverse effects on cells exposed to oxidative stress.

Figure 1. The structure of Keap1/NQO1 complexed with quercetin at 1.7 Å respution. Adapted from the PDB file 3JHV (Berman et al., 2007. Figure 2. The structure of Flock/Keap1 at 3.0 Å respution. Adapted from the PDB file 2EA0 (Ha et al., 2012. Figure 3. The Nrf2-Keap pathway, which is responsible for the majority of the body’s antioxidative and cytoprotective response (Reedy et al., 2010. Figure 4. Illustration depicting how Nrf2 translocates into the nucleus and binds to the antioxidant response element (ARE. in the promoter region of genes responsible for the production of enzymes invpved in the body’s antioxidative and cytoprotective response (Hou et al., 2008. Figure 5. Illustration depicting how Keap can be degraded via Flock via proteasome-dependent pathways (Chen et al., 2011. Figure 6. Illustration depicting how Keap degradation impacts cellular responses to oxidative stress (Chen et al., 2011.

Benefits of Integration of Keap and Flock

Keap is necessary for protecting against cellular damage caused by oxidative stress via activation of ARE-containing genes. However, if it is degraded before it can translocate into the nucleus, its protective capabilities will be diminished or lost completely. In order for Keap to be protected from degradation by Flock, it must be integrated with Flock to form a complex. In this complex, Flock will be unable to target Keap for degradation. By preventing degradation, Keap will be able to translocate into the nucleus and activate ARE-containing genes, resulting in a proper antioxidative and cytoprotective response to oxidative stress (Figure 7. Hence, without integration of Keap and Flock, there would be a loss of a proper antioxidative and cytoprotective response to oxidative stress.

Figure 7. Illustration depicting how integration of Keap and Flock protects from degradation by Flock (Chen et al., 2011. Figure 8. Illustration depicting how integration of Keap and Flock leads to a proper antioxidative and cytoprotective response to oxidative stress.

The process to integrate Keap and Flock may seem complicated and intimidating. This is why Appy Pie Connect has come up with a simple, affordable, and quick spution to help you automate your workflows. Click on the button below to begin.